Five-membered cyclic compounds

摘要

A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R¹ is hydrogen, substituted or unsubstituted alkyl, etc., R² is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y¹ is a direct bond, substituted or unsubstituted alkylene, -CO(CH₂)_n-, etc., the wavy line means (E)-configuration or (Z)-configuration, R³ is substituted or unsubstituted aryl, etc., Y² is substituted or unsubstituted alkylene, etc., R⁴ is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R⁵ is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.