| 发明名称 |
Death domain containing receptors |
| 摘要 |
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
|
| 申请公布号 |
US6951735(B2) |
申请公布日期 |
2005.10.04 |
| 申请号 |
US19990314889 |
申请日期 |
1999.05.19 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
YU GUO-LIANG;NI JIAN;DIXIT VISHVA;GENTZ REINER L.;DILLON PATRICK J. |
| 分类号 |
C12N15/09;A61K38/00;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/00;A61P43/00;C07H21/04;C07K14/705;C07K14/715;C12N1/21;C12N5/00;C12N5/10;C12N15/12;C12P21/02;C12R1/19;C12R1/91;(IPC1-7):C12N15/63 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
