| 摘要 |
Production of amides of formula Q-CO-NR6R7 (I) comprises reacting Q-X with CO and HNR6R7 in the presence of a base and a palladium complex of a diphosphine of formula R8R9P(CH2)nPR10R11; Q = a 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl or 1,3,5-triazin-2-yl group with one C atom substituted by OR and the other C atoms optionally substituted by 1-4C alkyl or aryl; R = optionally substituted aryl or heteroaryl; X = Cl, Br or I; R6 = H or 1-4C alkyl; R7 = optionally substituted aryl or heteroaryl; R8-R11 = optionally substituted phenyl; n = 3 or 4. Also claimed is a process as above where Q-X is prepared by reacting Q'-X with ROH, where Q' = a 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl or 1,3,5-triazin-2-yl group with one C atom substituted by Cl, Br or I and the other C atoms optionally substituted by 1-4C alkyl or aryl. |
