发明名称 |
SCREENING OF ANTI-VIRAL DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THIAZOLIDINONE DERIVATIVES |
摘要 |
The present invention relates to a method of screening for small organic molecules that directly inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding viral proteins (GBVPs), which comprises contacting a GAG with an GBVP in the presence of at least one candidate compound; and measuring the amount of the GAG bound to the GBVP or the amount of the GBVP bound to the GAG, wherein a significant decrease in GAG-GBVP binding as compared to GAG-GBVP binding in the absence of the candidate compound, identifies said compound as inhibitor of the GAG-GBVP interaction. The invention further provides pharmaceutical compositions comprising certain 2-thioxo-thiazolidinone derivatives, particularly useful against virus infections. |
申请公布号 |
WO2005089067(A2) |
申请公布日期 |
2005.09.29 |
申请号 |
WO2005IL00335 |
申请日期 |
2005.03.24 |
申请人 |
RIMONYX PHARMACEUTICALS LTD.;GREGOR, PAUL;HARRIS, NICHOLAS;ZHUK, REGINA |
发明人 |
GREGOR, PAUL;HARRIS, NICHOLAS;ZHUK, REGINA |
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