摘要 |
Provided is a method for site-specific chemical modification of an HIV gp41 - derived peptide, wherein during synthesis one or more amine groups of the HI V gp41 -derived peptide are chosen to blocked by a chemical protecting agent, and one or more amine groups are selected to be unprotected, and remain free to be reacted with an amine reactive functionality. The resultant HIV gp41- derived peptide may be used to produce a substantially homogeneous conjugate comprised of HIV gp41-derived peptide and polymer by covalently coupling the polymer to the one or more free (unprotected) amine groups of the HIV gp41- derived peptide.
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