发明名称 |
Enhancement of the stability of oligonucleotides comprising phosphorothioate linkages by addition of water-soluble antioxidants |
摘要 |
Compositions and methods for inhibition of desulfurization in oligonucleotides comprising one or more phosphorothioate linkages. Antioxidants which partition into the aqueous phase of bi-phasic or multi-phasic topical pharmaceutical formulations inhibit desulfurization of phosphorothioate oligonucleotides, resulting in enhanced oligonucleotide stability.
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申请公布号 |
US2005208528(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20040997221 |
申请日期 |
2004.11.24 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
KROTZ ACHIM;MEHTA RAHUL |
分类号 |
A61K31/7125;A61K47/18;A61K47/20;A61K47/22;(IPC1-7):C12Q1/68;C07H21/04 |
主分类号 |
A61K31/7125 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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