| 摘要 |
This disclosure provides a system for producing new biological agents useful for the treatment of inflammatory disease. Naturally occurring proteases are subject to cycles of mutagenesis and specificity screening, in order to obtain proteases having novel sequences and a refined specificity for cleaving particular cytokine receptors. Receptors like the p55 TNF receptor, and the receptors for IL-1, IL-6, IL-15, and IL-18 are suitable targets for proteases with improved efficacy and side effect profiles. The new proteases obtained according to this invention can be used for treating arthritis and other inflammatory conditions in a disease and patient specific manner. |
