发明名称 |
METHOD OF INHIBITING TUMOR PROLIFERATION |
摘要 |
It is intended to provide a method of inhibiting tumor proliferation which comprises the step of inhibiting the expression of PDGF-A or the binding of PDGF-A homodimer to PDGFR.alpha.. Activation of the PDGFR .alpha.-p70S6K signal transfer pathway by PDGF-AA, which is an important factor in tumor angiogenesis, relates to the prognosis of a patient suffering from tumor. By inhibiting the expression of PDGF-A in a tumor or a tissue around it or by inhibiting the binding of PDGF-A homodimer to PDGFR.alpha., angiogenesis in the tumor and retention of the blood vessels can be inhibited and thus the tumor proliferation can be inhibited.
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申请公布号 |
CA2560046(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
CA20052560046 |
申请日期 |
2005.03.15 |
申请人 |
DNAVEC RESEARCH INC. |
发明人 |
HASEGAWA, MAMORU;TSUTSUMI, NORIFUMI;YONEMITSU, YOSHIKAZU;SHIKADA, YASUNORI;SUEISHI, KATSUO |
分类号 |
A61K45/00;A61K31/7105;A61K35/76;A61K48/00;A61P35/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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