发明名称 |
HLA-DR specific antibodies, compositions and methods |
摘要 |
HLA-DR-specific monoclonal antibodies are provided that are capable of inducing apoptosis in HLA-DR-expressing tumor cells. Certain exemplary HLA-DR-specific antibodies exhibit reduced levels of immunosuppressive activity. Antibodies of the present invention will find use in diagnostic methods as well as in compositions and methods for the treatment of cancers associated with HLA-DR expressing tumor cells.
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申请公布号 |
US2005208048(A1) |
申请公布日期 |
2005.09.22 |
申请号 |
US20040013537 |
申请日期 |
2004.12.15 |
申请人 |
DENDREON CORPORATION |
发明人 |
MCMAHAN CATHY;STEPAN LARA P.;LAUS REINER;VIDOVIC DAMIR |
分类号 |
A61K;A61K39/395;C07K16/00;C07K16/28;(IPC1-7):C07K16/28 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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