SUGAR-CHAIN ASPARAGINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

摘要

An asparagine-linked oligosaccharide of the formula (1) given below having undeca- to tri-saccharides
<Chemistry id="chema01" num="0001"><Image id="ia01" he="33" wi="125" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein R<Sup>1</Sup> and R<Sup>2</Sup> are each a hydrogen atom or a group of the formulae (2) to (6) disclosed in the specification and may be the same or different, and Q is a biotin group or FITC group,
   an asparagine-linked oligosaccharide derivative containing at least one fucose in N-acetylglucosamine on the nonreducing terminal side of an asparagine-linked oligosaccharide wherein the amino group of asparagine is modified with a biotin group or FITC group,
   a microplate having immobilized thereto a biotinated asparagine-linked oligosaccharide, and
   an affinity column having immobilized thereto a biotinated asparagine-linked oligosaccharide.