发明名称 |
USE OF IMINOSUGAR DERIVATIVES TO INHIBIT ION CHANNEL ACTIVITY |
摘要 |
Disclosed are methods and kits to treat HCV infection by administering an iminosugar derivative compound that is effective to inhibit the activity of HCV p7 protein, and methods by which to screen for compounds that inhibit the activity of p7 protein or variants thereof. The disclosed N-substituted imino compounds, and pharmaceutical compositions thereof, inhibit the capability of HCV p7 to permeabilize membranes. Particularly efficacious compounds are imino sugars derived from N-alkylated piperidines. Also disclosed are methods for screening for potential HCV antiviral agents.
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申请公布号 |
KR20050092103(A) |
申请公布日期 |
2005.09.20 |
申请号 |
KR20057004647 |
申请日期 |
2005.03.18 |
申请人 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD |
发明人 |
ZITZMANN NICOLE;DWEK RAYMOND |
分类号 |
A61K31/40;A61K31/445;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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