THE USE OF ESTROGEN RECEPTOR ALPHA MODULATORS FOR THE TREATMENT OF MULTIPHE SCLEROSIS

摘要

The present invention provides methods of treating an autoimmune pathology in a mammal, comprising administering an agent with estrogen receptor a agonist activity in particular a selective estrogen receptor modulator, to the mammal in an amount sufficient to decrease production of TH-1 and/or TH-2 cytokines. Also provided is a method of selecting compounds useful for the treatment of multiple sclerosis, comprising selecting a compound which has estrogen receptor a agonist activity.