| 摘要 |
PROBLEM TO BE SOLVED: To produce 3-(diarylmethylene) oxyindole derivative having suppressing activity on vascular intima thickening, etc., in a safe, economical, simple and effective manner by reacting an oxyindole with a ketone using a specific base, solvent and condition. SOLUTION: An oxyindole of formula I [R is H, a (substituted) lower alkyl or a (substituted) benzyl] or its derivative is made to react with a ketone of formula II [R<1> and R<2> are each a (substituted) aryl] in the presence of an alkali metal hydroxide in toluene or t-amyl alcohol under dehydration refluxing to obtain 3-(diarylmethylene) oxyindole derivative of formula III. For example, oxyindole, 4,4'-dimethylbenzophenone and 85% potassium hydroxide are made to react in toluene to obtain 3-[bis (4-methylphenyl) methylene] oxyindole. |
