发明名称 |
METHODS AND COMPOSITIONS COMPRISING SUPRAMOLECULAR CONSTRUCTS |
摘要 |
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease. |
申请公布号 |
CA2556479(A1) |
申请公布日期 |
2005.09.09 |
申请号 |
CA20052556479 |
申请日期 |
2005.02.22 |
申请人 |
AC IMMUNE SA |
发明人 |
GREFERATH, RUTH;HICKMAN, DAVID;NICOLAU, YVES CLAUDE |
分类号 |
A61K39/385;A61K38/08;A61K38/10;A61K39/00;A61P25/28;C07K7/06;C07K7/08;C07K14/47 |
主分类号 |
A61K39/385 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|