| 摘要 |
PROBLEM TO BE SOLVED: To provide a practical method for producing an N-acylamino acid, by which amidocarbonylation reaction is efficiently advanced while controlling reduction in catalytic activity and leaching of palladium even by repeated use by using both a polymer-immobilized palladium catalyst and a solid acid catalyst. SOLUTION: The N-acylamino acid is obtained by reacting an aldehyde with an amide in the presence of a halogen compound, a polymer fixed palladium catalyst and a solid acid catalyst in an organic solvent under pressure of carbon monoxide. COPYRIGHT: (C)2005,JPO&NCIPI
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