| 摘要 |
<p>The invention concerns piperidine quinolyl derivatives of general formula (I)) wherein: R1a is hydrogen, halogen, hydroxy, amino, alkylamino, dialkylamino, hydroxyamino, alkyloxyamino or alkyl alkyloxy amino and R1b is hydrogen, or R1a and R1b form an oxo; R2 is carboxy, carboxymethyl or hydroxymethyl; R3 is alkyl substituted either by phenylthio optionally substituted by halogen, hydroxy, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkyloxycarbonyl, cyano or amino, or by cycloalkylthio (3 to 7 members) optionally substituted by halogen or trifluoromethyl, or by heteroarylthio (5 to 6 members and 1 to 4 heteroatoms selected among N, O and S), optionally substituted par halogen, hydroxy, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkyloxycarbonyl, cyano or amino or R3 is propargyl substituted by phenyl, or heteroaryl such as defined above; R4 is alkyl, alkenyl-CH2- or alkynyl-CH2-, cycloalkyl or cycloalkyl alkyl, in their various separated or mixed isomeric forms, as well as their salts. Said novel derivatives are potent antibacterial agents.</p> |
