发明名称 |
Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis |
摘要 |
An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). Methods of using the polypeptide to inhibit angiogenesis are also provided.
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申请公布号 |
US2005197298(A1) |
申请公布日期 |
2005.09.08 |
申请号 |
US20040982014 |
申请日期 |
2004.11.04 |
申请人 |
SCHIMMEL PAUL;WAKASUGI KEISUKE;FRIEDLANDER MARTIN |
发明人 |
SCHIMMEL PAUL;WAKASUGI KEISUKE;FRIEDLANDER MARTIN |
分类号 |
A61K38/00;C07H21/04;C07K14/515;C07K14/52;C12N9/00;(IPC1-7):A61K38/08;A61K48/00;C12Q1/68;C12N9/22 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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