| 摘要 |
The present invention relates to a recycling process for the preparation of solid phase bonded 2- chlorotrityl chloride (2-CTC resin) useful for solid phase peptide synthesis. Specifically what is claimed is a process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) of formula I, wherein Ps is a polymeric support and n has the following meaning: 1 >= n> 0 comprising the reaction of solid phase bonded 2- chlorotrityl of formula II, wherein R is OH or/and OC1-4-alkyl or/and NR'R" wherein R' and R" independently of each other represent C1-4-alkyl, or R' and R" together with the nitrogen to which they are bonded represent a 5 to 8 membered heterocyclic radical in the presence of a chlorinating agent and an organic solvent.
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