发明名称 |
Preparation of further diagnostic agents |
摘要 |
Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 mum, targeted to selected areas of the body or of prolonged life in the circulation.
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申请公布号 |
US6939530(B2) |
申请公布日期 |
2005.09.06 |
申请号 |
US20020175853 |
申请日期 |
2002.06.21 |
申请人 |
QUADRANT DRUG DELIVERY LIMITED |
发明人 |
SUTTON ANDREW DEREK;JOHNSON RICHARD ALAN |
分类号 |
A61K9/50;A61B8/00;A61K9/16;A61K47/42;A61K49/00;A61K49/22;B01J13/04;(IPC1-7):A61B8/00;B01F17/00 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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