发明名称 |
PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS |
摘要 |
Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-l-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula (II), wherein R<1> is selected from the group consisting of 2-thienyl, 2-furanyl and phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkoxy groups, and wherein R<2> is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein the corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Furthermore provided are salts of a carboxylic acid with said aminoketones and the aminoalcohols obtained by asymmetriacally hydrogenating said aminoketones, respectively. |
申请公布号 |
WO2005080370(A1) |
申请公布日期 |
2005.09.01 |
申请号 |
WO2005EP01781 |
申请日期 |
2005.02.21 |
申请人 |
LONZA AG;MICHEL, DOMINIQUE;METTLER, HANSPETER;MCGARRITY, JOHN |
发明人 |
MICHEL, DOMINIQUE;METTLER, HANSPETER;MCGARRITY, JOHN |
分类号 |
C07B53/00;C07C213/00;C07D333/20;C07D333/22 |
主分类号 |
C07B53/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|