DIFFERENT DENDRITIC CELL SUBSETS

摘要

It is intended to provide expired dendritic cells having the following characteristics (E1) to (E3): (E1) not shifting into the matured type due to the action of a natural immune stimulant and a permanent immune potentiator; (E2) having the same shape as immature DC; and (E3) expressing IL-10. It is also intended to provide permanently activated dendritic cells having the following characteristics: (M2-1) having projecting dendrites and forming an aggregation cluster; (M2-2) being capable of activating unreacted cytotoxic T lymphocytes (CTL); (M2-3) having stable properties under the action of anti-CD40 monoclonal antibody; and (M2-4) showing a high expression dose of at least one member selected from the group consisting of CD80, CD83 and CD86.