A METHOD FOR THE IDENTIFICATION OF IRS PROTEIN KINASE INHIBITORS OR AGONISTS

摘要

The present invention relates to a method for the identification of an IRS protein kinase inhibitor, comprising the steps of a) bringing into contact PKC-zeta with at least one IRS peptide comprising at least one PKC-zeta-Ser-phosphorylation site in the presence of at least one putative inhibitor, and b) measuring the phosphorylation of the PKC-zeta-Ser-phosphorylation site.