发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS |
摘要 |
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor. |
申请公布号 |
EP1461061(A4) |
申请公布日期 |
2005.08.31 |
申请号 |
EP20020786859 |
申请日期 |
2002.12.02 |
申请人 |
CHEMOCENTRYX INC |
发明人 |
BURNS, JENNIFER, M.;MIAO, ZHENHUA;WEI, ZHENG;HOWARD, MAUREEN, C.;PREMACK, BRETT, A.;SCHALL, THOMAS, J. |
分类号 |
G01N33/50;A61K45/00;A61P29/00;C07K16/28;C12N5/10;C12N15/09;C12Q1/02;G01N33/15;G01N33/574;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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