发明名称 |
Methods and compositions for effecting homologous recombination |
摘要 |
This invention concerns a method for effecting directed mutagenesis based on a guided homologous recombination system that comprises (i) a triple helix forming oligonucleotide, (ii) a donor nucleic acid segment, and (iii) an adapter segment comprising an oligonucleotide sequence able to bind at least a portion of said donor nucleic acid through Watson-Crick base pairing.
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申请公布号 |
US6936418(B2) |
申请公布日期 |
2005.08.30 |
申请号 |
US20020053526 |
申请日期 |
2002.01.18 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
DUTREIX MARIE;SUN JIAN-SHENG;BIET ELODIE;MAURISSE ROSALIE;FEUGEAS JEAN-PAUL |
分类号 |
C12N15/09;A61K48/00;C07H21/04;C12N15/10;C12N15/90;(IPC1-7):C12Q1/68;C12N15/87;C07H21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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