发明名称 |
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
摘要 |
Disclosed herein are compounds of formula Ar1-X-W-Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)- N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.
|
申请公布号 |
KR20050084112(A) |
申请公布日期 |
2005.08.26 |
申请号 |
KR20057009999 |
申请日期 |
2005.06.02 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
SIMONEAU BRUNO;THAVONEKHAM BOUNKHAM;LANDRY SERGE;O'MEARA JEFFREY;YOAKIM CHRISTIANE;FAUCHER ANNE MARIE |
分类号 |
A61K31/167;A61K31/41;A61K31/4164;A61K31/4178;A61K31/4184;A61K31/4192;A61K31/4439;C07D233/84;C07D235/28;C07D249/12;C07D257/04;C07D257/06;C07D307/54;C07D401/04;C07D401/12;C07D403/12;C07D405/12;C07D409/12;(IPC1-7):A61K31/41;A61K31/419;A61K31/443;A61K31/418 |
主分类号 |
A61K31/167 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|