发明名称 |
Corona-virus-like particles comprising functionally deleted genomes |
摘要 |
The invention relates to the field of coronaviruses and diagnosis, therapeutic use, and vaccines therefor. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein which methods include decreasing the contact between heptad repeat regions of the coronavirus spike protein. The invention provides a peptide comprising a heptad repeat region of a coronaviral spike protein and/or a functional fragment and/or a derivative thereof. The invention also provides antibodies and compounds inhibiting coronaviral infection of cells, and/or cell-to-cell fusion. The invention also includes heptad repeat regions and a fusion peptide of SARS-CoV.
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申请公布号 |
US2005186575(A1) |
申请公布日期 |
2005.08.25 |
申请号 |
US20030750411 |
申请日期 |
2003.12.30 |
申请人 |
ROTTIER PETRUS J.M.;BOSCH BEREND J. |
发明人 |
ROTTIER PETRUS J.M.;BOSCH BEREND J. |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K39/215;A61K39/225;A61K39/395;A61K48/00;A61K49/00;A61P1/16;A61P7/00;A61P7/04;A61P7/06;A61P11/00;A61P31/00;A61P31/12;A61P31/16;A61P31/20;A61P31/22;A61P35/02;A61P37/04;C07K14/165;C07K16/10;C12N5/06;C12N5/16;C12N7/00;C12N7/04;C12N15/86;C12P21/06;C12Q1/68;C12Q1/70;G01N33/569;(IPC1-7):C12Q1/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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