发明名称 Zinc-free and low-zinc insulin preparations having improved stability
摘要 The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.
申请公布号 US2005187143(A1) 申请公布日期 2005.08.25
申请号 US20040007155 申请日期 2004.12.09
申请人 AVENTIS PHARMA DEUTSCHLAND GMBH 发明人 BODERKE PETER
分类号 A61K9/00;A61K38/28;A61K47/10;A61K47/12;A61K47/14;A61K47/18;A61K47/24;A61K47/26;A61K47/28;A61K47/36;A61P3/08;A61P3/10;(IPC1-7):A61K38/28 主分类号 A61K9/00
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