| 摘要 |
The present invention relates to pharmaceutical compositions and methods wherein L-methadone and at least one other opioid analgesic are administered in amounts effective to potentiate a synergistic antinociceptive response to moderate and severe pain, preferably with decreased dependence and tolerance potential. Synergistic potentiation of analgesia through administration of pharmaceutical compositions comprising L-methadone and at least one other opioid analgesic provides a new and improved approach to pain management.
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