DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN MELATONIN RECEPTOR TYPE 1A (MTNR1A)

摘要

The invention provides a human MTNR1A which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseaes, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseaes, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MTNR1A as well as pharmaceutical compositions comprising such compounds.