发明名称 |
Methods and compositions for enhancing the efficacy and specificity of RNAi |
摘要 |
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
|
申请公布号 |
US2005186586(A1) |
申请公布日期 |
2005.08.25 |
申请号 |
US20040912440 |
申请日期 |
2004.08.04 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
ZAMORE PHILLIP D.;HUTVAGNER GYORGY;SCHWARZ DIANNE;SIMARD MARTIN |
分类号 |
A61K48/00;C12N15/11;C12N15/113;C12N15/85;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|