NOVEL CRYSTAL FORMS OF ONDANSETRON, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THE NOVEL FORMS AND METHODS FOR TREATING NAUSEA USING THEM

摘要

Ondansetron crystalline Forms A and B are useful in the treatment of nausea and vomiting. Form B has a uniquely high melting point of about 244° C. and both forms are stable against thermally induced polymorphic transition from 30° C. up to their melting points.