A METHOD OF PREPARATION OF (R)-(-)-5(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE

摘要

A method of preparation of (R)-(-)-5-(2-aminopropyl)-2- methoxybenzenesulfonamide of formula I and its use for production tamsulosin . A protective group is introduced to N-[(1R)-2~(4-methoxyphenyl)-1-methylethy l]- N- [(1 R)-1-phenylethyl)]amine and the resulting amide of formula IX is chlorosulfonated and the resulting sulfochloride is converted to a sulfonami de of formula X, from which the compound of formula I is obtained by hydrogenation.