C-TERMINAL p53 PALINDROMIC PEPTIDE THAT INDUCES APOPTOSIS OF CELLS WITH ABERRANT p53 AND USES THEREOF
摘要
<p>Disclosed are polypeptides comprising a first segment of continuous amino acids having the sequence AQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD (SEQ ID N0. 1) covalently linked to a second segment of continuous amino acids having the sequence DSDPGETKFMLKKHRSTSQGKKSKLHSSHARSGGPEKGAQA (SEQ ID N0. 2), or at least two of each covalently linked to each ether. The polypeptides are shown to induce apoptosis of cancer cells that contain mutant p53 or over-expressed wild-type p53.</p>
申请公布号
WO2005074521(A2)
申请公布日期
2005.08.18
申请号
WO2005US02543
申请日期
2005.01.27
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;FINE, ROBERT, L.;BRANDT-RAUF, PAUL;MAO, YUEHA