METHODS OF PREVENTING RESTENOSIS

摘要

The present invention is directed to a method of inhibiting smooth muscle cell migration both in vitro and in vivo by administering an effective amount of a compound that inhibits signaling in the Ras-Raf-Erk-MEKK1 pathway. The present invention is further directed to the treatment of restenosis by administering such a compound via an implantable stent. Examples of such compounds include benzoquinone ansamycins (e.g., 17-(allylamino)-17-demethoxygeldanamycin).