| 摘要 |
The invention relates to a method for producing a conjugate of a polynucleotide and a polysaccharide, said method comprising the following steps: a) an aldonic acid of the polysaccharide or a derivative thereof is provided; b) the aldonic acid is reacted with an alcohol derivative, preferably a carbonate derivative of an alcohol, to form an aldonic acid ester, preferably an activated aldonic acid ester; and c) the aldonic acid ester is reacted with the polynucleotide, said polynucleotide comprising a functional amino group. The aldonic acid is reacted with the alcohol derivative in step (b) in a dry aprotic polar solvent.
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