Hybrid proteins of beta-lactamase class A

摘要

The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a hybrid beta -lactamase class A protein, wherein in that the beta -lactamase class A protein is bearing at least one heterologous sequence in a region located between two neighboring alpha helices of the beta -lactamase sequence, wherein the region is selected from: a) the region forming a juncture between alpha helix 8 and alpha helix 9 of the TEM-1 beta -lactamase; b) the region forming a juncture between the alpha helices of homologous beta -lactamases class A, which correspond to the alpha helix 8 and alpha helix 9 of the TEM-1 beta -lactamase.