| 摘要 |
The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH<SUB>2</SUB>; Y is selected from C, CH, CH<SUB>2</SUB>, S, NR, CH<SUB>2</SUB>-CH<SUB>2</SUB>, H<SUB>2</SUB>C-CH, HC-CH<SUB>2</SUB>, C-CH<SUB>2</SUB>, H<SUB>2</SUB>C-C, or C-C; one or more of the hydrogen atoms can optionally be substituted by one or more substituents R'; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R' is independently H, -CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, -OH, -SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.
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