IDENTIFICATION AND USE OF COFACTOR INDEPENDENT PHOSPHOGLYCERATE MUTASE AS A DRUG TARGET
摘要
Present embodiments of the invention describe computational methods for performing a systematic, genome-wide search for novel drug targets in pathogenic organisms for example, the human filarial parasites. Cofactor independent phosphoglycerate mutase (iPGM) was identified by this search as a candidate target for identifying therapeutic agents for use in treating animal or plant subjects infected with parasitic nematodes, microbial pathogens including microsporidia, fungi etc. A consensus amino acid or nucleotide sequence that characterizes iPGM is further provided.
申请公布号
WO2005020886(A3)
申请公布日期
2005.08.11
申请号
WO2004US18200
申请日期
2004.06.04
申请人
NEW ENGLAND BIOLABS, INC.;CARLOW, CLOTILDE, K., S.;ZHANG, YINHUA;FOSTER, JEREMY;KUMAR, SANJAY
发明人
CARLOW, CLOTILDE, K., S.;ZHANG, YINHUA;FOSTER, JEREMY;KUMAR, SANJAY