The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided.
申请公布号
WO2004050842(A3)
申请公布日期
2005.08.11
申请号
WO2003US38091
申请日期
2003.11.26
申请人
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;KASTAN, MICHAEL, B.;BAKKENIST, CHRISTOPHER, J.
