摘要 |
Compounds useful for lowering beta amyloid levels are provided. The compound s have the structure of formula Ia: wherein, RI is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is pheny1, substituted phenyl , heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is low er alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkeny l, substituted alkenyl, alkynyl, substituted alkyny1, phenyl, substìtuted pheny l, cycloalkyl, or substìtuted cycloalkyl; W, X and Y are independently CR7 or N ; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.</SDOAB >
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申请人 |
WYETH |
发明人 |
MORRIS, KOI MICHELE;CAGGIANO, THOMAS JOSEPH;SABALSKI, JOAN E.;KUBRAK, DENNIS MARTIN;HURYN, DONNA M.;RESNICK, LYNN;BERKOWITZ, JOSHUA D.;KREFT, ANTHONY FRANK |