| 摘要 |
The invention relates to human antibodies, preferably recombinant human antibodies which are specifically bound to human tumour necrotic factor alpha(TNFalpha). The antibodies have high afinity to hTNFalpha, e.g. Kd = 10-8 M or less, low hTNFalpha dissociate velocity, e.g. Koff = 10-3sec-1 or less, and neutralize the hTNFalpha activity in vitro and in vivo. Antibody of this invention can be an antibody with its full length or its antigene-binding part. The antibodies or parts thereof are applicable for the detection of hTNFalpha and for the inhibition of hTNFalpha activity, for example in patients suffering from indispositions where the hTNFalpha activity is harmfull. The invention also relates to nucleinic acids, vectors and host cells for the expression of recombinant human antibodies and to methods for their synthetization.
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