发明名称 |
O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
摘要 |
The present disclsoure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and azalides by regioselective 11-O-alkylation of macrolides and azalides having a vicinal diol system, using diazoalkanes in the presence of transition-metal halides or boric acid as catalysts. In another aspect, the disclosure relates to uses of the 11-O-alkyl macrolides and azalides as antibacterial agents or intermediates for the synthesis of other antibacterial agents.
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申请公布号 |
US2005164958(A1) |
申请公布日期 |
2005.07.28 |
申请号 |
US20040851768 |
申请日期 |
2004.05.21 |
申请人 |
PLIVA-ISTRAZIVACKI INSTITUT D.O.O. |
发明人 |
KIDEMET DAVOR;LAZAREVSKI GORJANA;DEREK MARKO;LELJAK MARIJA |
分类号 |
A61K31/7052;C07H17/00;C07H17/08;(IPC1-7):A61K31/705 |
主分类号 |
A61K31/7052 |
代理机构 |
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地址 |
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