METHODS AND COMPOSITIONS FOR THE INHIBITION OF CATHEPSINS

摘要

Methods and compositions for modulating cell death by contacting a cell with
an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. In
addition, methods of treating a subject by providing the subject a composition
that includes an Spi2A polypeptide or an Spi2A polypeptide equivalent are
disclosed. The Spi2A polypeptide and Spi2A polypeptide equivalent can be
delivered to the subject using gene therapy techniques. The subject can be a
patient with a disease associated with an abnormal rate of cell death, such as
septic shock or myocardial infarction. Also disclosed are methods of preparing
and storing donor granulocytes, involving contacting the donor granulocytes
with an Spi2A polypeptide or an Spi2A polypeptide equivalent.