| 发明名称 |
TRIF-related adaptor molecule (TRAM) and uses thereof |
| 摘要 |
A Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) has been identified. TRAM acts specifically in the TLR4 signaling pathway. The invention includes compounds useful for modulating TLR signaling by modulating the effects of TRAM.
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| 申请公布号 |
US2005158799(A1) |
申请公布日期 |
2005.07.21 |
| 申请号 |
US20040968598 |
申请日期 |
2004.10.18 |
| 申请人 |
FITZGERALD KATHERINE A.;ROWE DANIEL C.;GOLENBOCK DOUGLAS T. |
发明人 |
FITZGERALD KATHERINE A.;ROWE DANIEL C.;GOLENBOCK DOUGLAS T. |
| 分类号 |
C07H21/04;C07K14/47;C07K14/715;C07K16/28;C12N5/06;G01N33/53;G01N33/567;(IPC1-7):G01N33/53 |
主分类号 |
C07H21/04 |
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