Retrograde delivery of pharmacologic and diagnostic agents via venous circulation

摘要

System for the retrograde delivery of fluid containing pharmacologic or diagnostic fluids to a patient's microcirculatory system through a vein which drains the microcirculatory system comprising a catheter having an inflatable balloon at the distal end thereof and adapted to be inserted into and advanced through a patient's venous system to a position in the vein which drains the microcirculatory system. The balloon is inflated to block the interior of the vein and prevent the fluid from flowing in the vein in the same direction as normal blood out-flow. Fluids containing pharmacologic or diagnostic agents are introduced through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough. The fluid is maintained in the microcirculatory system for a minimum period and at sufficient pressure to facilitate the desired performance of the pharmacologic or diagnostic agent.