摘要 |
A compound of the general formula (I) or pharmaceutically acceptable prodrug s, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 ar e optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) a re also provided. Further provided are methods of treating tyrosine kinase- associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).
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申请人 |
CYTOPIA RESEARCH PTY LTD |
发明人 |
TREUTLEIN, HERBERT RUDOLF;BU, XIANYONG;STYLES, MICHELLE LEANNE;ZENG, JUN;BURNS, CHRISTOPHER JOHN;WILKS, ANDREW FREDERICK;KLING, MARCEL ROBERT |