发明名称 |
Methods and materials for the inhibition of transplant rejection |
摘要 |
The present invention provides compositions and methods of inhibiting transplant rejection in a mammal, comprising administering one or more transplant rejection inhibiting compounds to the mammal, wherein at least one compound includes an antibody that immunoreacts with the extracellular domain of the SPEX polypeptide. The present invention also provides a method of decreasing an expression of the SPEX polypeptide on a lymphocyte that expresses the SPEX polypeptide. The present invention further provides a method of identifying antibodies that immunoreact with the extracellular domain of the SPEX polypeptide and inhibit transplant rejection. |
申请公布号 |
US2005152893(A1) |
申请公布日期 |
2005.07.14 |
申请号 |
US20040964215 |
申请日期 |
2004.10.12 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
KAYE JONATHAN |
分类号 |
A61K31/4745;A61K31/573;A61K38/13;A61K39/395;C07H21/04;C07K16/18;C12N5/06;(IPC1-7):A61K39/395;A61K31/474 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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