METHOD FOR ANALYZING (1-HYDROXYETHYLIDENE)BIS-PHOSPHONATE

摘要

PROBLEM TO BE SOLVED: To provide an elution testing method of an oral agent containing (1-hydroyethylidene)bis-phosphonate or its salt as an effective component. SOLUTION: In the elution testing method of the oral agent containing (1-hydroxyethylidene)bis-phosphonate or its salt as the effective component, a column packed with an anion exchange resin as a filler is used under a condition of the number of theoretical plates of≥2,500 and a degree of separation of≥2.0 and a change in electric conductivity is sensed to separate (1-hydroxyethylidene)bis-phosphonate, a phosphoric acid and citric acid to analyze (1-hydroxyethylidene)bis-phosphonate. COPYRIGHT: (C)2005,JPO&NCIPI