发明名称 |
Carotenoid ether analogs or derivatives for controlling connexin 43 expression |
摘要 |
A method of controlling (e.g., influencing or affecting) connexin 43 expression in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. In some embodiments, controlling connexin 43 expression in a subject may effectively treat cardiac arrhythmia and/or cancerous and pre-cancerous cells in a subject. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ether functionality.
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申请公布号 |
US2005148517(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
US20040793651 |
申请日期 |
2004.03.04 |
申请人 |
LOCKWOOD SAMUEL F.;O'MALLEY SEAN;WATUMULL DAVID G.;HIX LAURA M.;JACKSON HENRY;NADOLSKI GEOFF |
发明人 |
LOCKWOOD SAMUEL F.;O'MALLEY SEAN;WATUMULL DAVID G.;HIX LAURA M.;JACKSON HENRY;NADOLSKI GEOFF |
分类号 |
A01N27/00;A61K31/01;A61K31/015;A61K31/045;A61K31/07;A61K31/075;A61K31/12;A61K31/13;A61K31/185;A61K31/215;A61K31/225;A61K31/255;A61K31/325;A61K31/401;A61K31/404;A61K31/4172;A61K31/535;A61K31/537;A61K31/66;A61K31/665;A61K31/70;A61K31/704;A61K31/715;C07D207/16;C07D233/60;C07D265/30;C07D307/58;C07F9/02;C07F9/117;C07H13/04;(IPC1-7):A61K31/704 |
主分类号 |
A01N27/00 |
代理机构 |
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代理人 |
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地址 |
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