NF-kappaB activation inhibitors, and their pharmaceutical uses

摘要

Compounds inhibiting the activation of the nuclear factor kappaB (NF-kappaB) are used for the preparation of medications adapted for the treatment of malignant hemopathies and solid tumors, and for the prevention of the appearance or the treatment, of phenomena of resistance to cytotoxic molecules used in the scope of treatment of the above pathologies, appearing in patients treated with these molecules when the latter are adapted to activate NF-kappaB.